Introduction in to the Endocannabinoid System!

ENS

The Endocannabinoid System- The system by which our body interacts with Cannabinoids

  • The Endocannabinoid system is believed to have developed around 600 million years ago.
  • Most if not all complex creature’s from fish to humans have an endocannabinoid system.
  • The primary function of the Endocannabinoid System is to promote cellular homeostasis.
  • The endocannabinoid does this by responding to mechanical or stress induced traumas
  • This response to trauma is based on the type and location of the trauma
  • The response is adaptive and based upon which agonist interacts with the Cannabinoid Receptors
  • This is called “agonist trafficking” or “retrograde signaling”
  • The Endocannabinoid system has 2 main receptors
  • The CB1 and CB2 Receptors are the most common and researched of these receptors
  • CB1 receptors are mainly located in the Nervous System but can be found throughout the bodies; Organs, Connective Tissues, Reproductive Tissues, Adipose Tissues, and other glands
  • CB2 Receptors are located mainly in the Immune System but can be also be created or upregulated to tissues where CB2 receptors are not common.
  • Anandamide (AEA) and 2-Arachiodonoylgly (2-AG) are both Endogenous Cannabinoids (Endogenous- Growing or Originating from within an organism) Both of these naturally occurring cannabinoids regularly interact with the ENS
  • AEA and 2-AG are the 2 most common and researched Endogenous cannabinoids.
  • THC and CBD are the 2 most researched Exogenous cannabinoids
  • Endogenous and exogenous cannabinoids interact with the ENS through the same receptors
  • Due to “agonist trafficking” interactions with the endocannabinoid system can be complex and overlap with many of the bodies functions and system
  • A few of the areas where CB1 receptors appear to have some of the highest densities are Hippocampus, Cerebral Cortex, Cerebellum, Amygdaloid nucleus, Basil ganglia.
  • This can help account for effects on Short term memory, Cognition, Mood/Emotions, Motor function, and Nociception.
  • The Anti-nociceptive effects can be effective in reducing Acute pain, Chronic inflammatory pain, and Neuropathic pain
  • CB1 signaling can decrease the release activators and sensitizers around the site of tissue injuries and quickly begin to dampen pain
  • CB2 signaling can decrease the release of activators and sensitizers from neighboring mast cells and macrophages and begin helping the immune system stem off and imbalance’s
  • CB2 receptors have been known to have an increased presence in the peripheral nerves after an injury.
  • The ENS is all but absent in the brain stem and cardio respiratory centers, leading to high LD50. That ratio is often calculated at a 1:20,000 or 1:40,000 ratio, meaning you would have to consume 20,000 to 40,000 times as much cannabis as is in one joint weighing .9gs in a 15-30 minute window of time.
  • There are situations where the ENS can become down regulated due to regular over consumption or by other functions of the bodies system (usually malignant).
  • In the case of regular over consumption or even sporadic over consumption, a simple way to restore normal ENS density can be simple abstention.
  • In what has been called Cannabinoid Deficiency Syndrome, several symptoms and ailments have been implicated. Uncompensated schizophrenia, Chronic motion sickness, M.S, Fibromyalgia, Huntingtons, Menstrual symptoms , Uncompensated Parkinsnsn, IBS, and Uncompensated anorexia to name a few.